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Stafeev, I., Agareva, M., Michurina, S., Tomilova, A., Shestakova, E., Zubkova, E., et al

In this study, a high concentration cholesterol-induced lipotoxicity was observed in INS-1 cells, including inhibited cell viability and insulin secretion

Insulin resistance is one of the primary contributors to NAFLD

More experimental studies are needed, as an improved translation process could significantly enhance the global adoption and use of PROMs

Journal reference: Corrao S, Pollicino C, Maggio D, Torres A and Argano C (2024) Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence